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Article

Identification of RASAL1 as a major tumor suppressor gene in thyroid cancer.

Journal of the National Cancer Institute - 6 Nov 2013

Liu Dingxie, Yang Chongfei, Bojdani Ermal, Murugan Avaniyapuram Kannan, Xing Mingzhao

Abstract excerpt

BACKGROUND: RAS-coupled MAPK and PI3K pathways play a fundamental role in thyroid tumorigenesis, and classical genetic alterations upregulating these pathways are well characterized. We hypothesized that gene abnormality of negative modulators of these signaling pathways might be an important alternative genetic background for thyroid cancer. METHODS: By examining gene expression patterns of negative modulators...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24136889
DOI: 10.1093/jnci/djt249
PMCID: PMC3818169

Genes

RASAL1
BRAF
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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