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Article

mTOR Pathway Overactivation in BRAF Mutated Papillary Thyroid Carcinoma

2 May 2012

Abstract excerpt

CONTEXT: There are several genetic and molecular evidences suggesting dysregulation of the mammalian target of rapamycin (mTOR) pathway in thyroid neoplasia. Activation of the phosphatidylinositol-3-kinase/AKT pathway by RET/PTC and mutant RAS has already been demonstrated, but no data have been reported for the BRAF(V600E) mutation. OBJECTIVE: The aim of this study was to evaluate the activation pattern of the...

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Share to PI3K/AKT/mTOR signaling in cancer
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Identifiers

PMID: 22549934
DOI: 10.1210/jc.2011-2748

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