Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Thyroid-stimulating hormone/cAMP and glycogen synthase kinase 3beta elicit opposing effects on Rap1GAP stability.

The Journal of biological chemistry - 13 Feb 2004

Tsygankova Oxana M, Feshchenko Elena, Klein Peter S, Meinkoth Judy L

Abstract excerpt

Beyond regulating Rap activity, little is known regarding the regulation and function of the Rap GTPase-activating protein Rap1GAP. Tuberin and E6TP1 protein levels are tightly regulated through ubiquitin-mediated proteolysis. A role for these RapGAPs, along with SPA-1, as tumor suppressors has b...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bromodeoxyuridine
Share to Glycogen Synthase Kinase 3
Share to Glycogen Synthase Kinase 3 beta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to rap1 GTP-Binding Proteins

Share to Ribosomal Protein S6 Kinases, 70-kDa

Share to Thyroid Gland

Share to Thyrotropin

Share to Tuberous Sclerosis Complex 2 Protein

Source

Identifiers

PMID: 14660640
DOI: 10.1074/jbc.M305824200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-14660640-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Thyroid-stimulating hormone/cAMP and glycogen synthase kinase 3beta elicit opposing effects on Rap1GAP stability.PMID 14660640Read ↗

Coordinated regulation of Rap1 and thyroid differentiation by cyclic AMP and protein kinase A.Semantic proximity Read ↗

Loss of Rap1GAP in papillary thyroid cancer.Semantic proximity Read ↗

The tuberous sclerosis genes and regulation of the cyclin-dependent kinase inhibitor p27.Semantic proximity Read ↗

Downregulation of Rap1GAP through epigenetic silencing and loss of heterozygosity promotes invasion and progression of thyroid tumors.Semantic proximity Read ↗

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling.Semantic proximity Read ↗

cAMP inhibition of Akt is mediated by activated and phosphorylated Rap1b.Semantic proximity Read ↗

The p85 regulatory subunit of PI3K mediates TSH-cAMP-PKA growth and survival signals.Semantic proximity Read ↗

cAMP-dependent oncogenic action of Rap1b in the thyroid gland.Semantic proximity Read ↗

Cell size regulation by the human TSC tumor suppressor proteins depends on PI3K and FKBP38Semantic proximity Read ↗

Novel functions of thyroid hormone receptor mutants: beyond nucleus-initiated transcription.Semantic proximity Read ↗

Aberrant accumulation of PTTG1 induced by a mutated thyroid hormone beta receptor inhibits mitotic progression.Semantic proximity Read ↗

The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.