Article
Transposon insertional mutagenesis in mice identifies human breast cancer susceptibility genes and signatures for stratification.
Proceedings of the National Academy of Sciences of the United States of America - 14 Mar 2017
Chen Liming, Jenjaroenpun Piroon, Pillai Andrea Mun Ching, Ivshina Anna V, Ow Ghim Siong, Efthimios Motakis, Zhiqun Tang, Tan Tuan Zea, Lee Song-Choon, Rogers Keith, Ward Jerrold M, Mori Seiichi, Adams David J, Jenkins Nancy A, Copeland Neal G, Ban Kenneth Hon-Kim, Kuznetsov Vladimir A, Thiery Jean Paul
Abstract excerpt
Robust prognostic gene signatures and therapeutic targets are difficult to derive from expression profiling because of the significant heterogeneity within breast cancer (BC) subtypes. Here, we performed forward genetic screening in mice using Sleeping Beauty transposon mutagenesis to identify candidate BC driver genes in an unbiased manner, using a stabilized N-terminal truncated β-catenin gene as a sensitizer....
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