Article
Novel candidate cancer genes identified by a large-scale cross-species comparative oncogenomics approach.
Cancer research - 1 Feb 2010
Mattison Jenny, Kool Jaap, Uren Anthony G, de Ridder Jeroen, Wessels Lodewyk, Jonkers Jos, Bignell Graham R, Butler Adam, Rust Alistair G, Brosch Markus, Wilson Catherine H, van der Weyden Louise, Largaespada David A, Stratton Michael R, Futreal P Andy, van Lohuizen Maarten, Berns Anton, Collier Lara S, Hubbard Tim, Adams David J
Abstract excerpt
Comparative genomic hybridization (CGH) can reveal important disease genes but the large regions identified could sometimes contain hundreds of genes. Here we combine high-resolution CGH analysis of 598 human cancer cell lines with insertion sites isolated from 1,005 mouse tumors induced with the murine leukemia virus (MuLV). This cross-species oncogenomic analysis revealed candidate tumor suppressor genes and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.