Article
Polygenic in vivo validation of cancer mutations using transposons.
Genome biology - 27 Sept 2014
Chew Su Kit, Lu Dong, Campos Lia S, Scott Kenneth L, Saci Abdel, Wang Juexuan, Collinson Adam, Raine Keiran, Hinton Jonathan, Teague Jon W, Jones David, Menzies Andrew, Butler Adam P, Gamble John, O'Meara Sarah, McLaren Stuart, Chin Lynda, Liu Pentao, Futreal P Andrew
Abstract excerpt
The in vivo validation of cancer mutations and genes identified in cancer genomics is resource-intensive because of the low throughput of animal experiments. We describe a mouse model that allows multiple cancer mutations to be validated in each animal line. Animal lines are generated with multiple candidate cancer mutations using transposons. The candidate cancer genes are tagged and randomly expressed in...
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