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Article

A mouse model for <i>EML4-ALK</i> -positive lung cancer

8 Dec 2008

Abstract excerpt

EML4-ALK is a fusion-type protein tyrosine kinase that is generated in human non-small-cell lung cancer (NSCLC) as a result of a recurrent chromosome inversion, inv (2)(p21p23). Although mouse 3T3 fibroblasts expressing human EML4-ALK form transformed foci in culture and s.c. tumors in nude mice, it has remained unclear whether this fusion protein plays an essential role in the carcinogenesis of NSCLC. To address...

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PMID: 19064915
DOI: 10.1073/pnas.0805381105

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