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Article

Mouse Model for ROS1-Rearranged Lung Cancer

13 Feb 2013

Abstract excerpt

Genetic rearrangement of the ROS1 receptor tyrosine kinase was recently identified as a distinct molecular signature for human non-small cell lung cancer (NSCLC). However, direct evidence of lung carcinogenesis induced by ROS1 fusion genes remains to be verified. The present study shows that EZR-ROS1 plays an essential role in the oncogenesis of NSCLC harboring the fusion gene. EZR-ROS1 was identified in four...

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PMID: 23418494
DOI: 10.1371/journal.pone.0056010

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