Article
Development of new mouse lung tumor models expressing EGFR T790M mutants associated with clinical resistance to kinase inhibitors.
PloS one - 29 Aug 2007
Regales Lucia, Balak Marissa N, Gong Yixuan, Politi Katerina, Sawai Ayana, Le Carl, Koutcher Jason A, Solit David B, Rosen Neal, Zakowski Maureen F, Pao William
Abstract excerpt
BACKGROUND: The EGFR T790M mutation confers acquired resistance to kinase inhibitors in human EGFR mutant lung adenocarcinoma, is occasionally detected before treatment, and may confer genetic susceptibility to lung cancer. METHODOLOGY/PRINCIPAL FINDINGS: To study further its role in lung tumorigenesis, we developed mice with inducible expression in type II pneumocytes of EGFR(T790M) alone or together with a...
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