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Article

Binding-gating coupling in a nondesensitizing alpha7 nicotinic receptor A single channel pharmacological study.

Biochimica et biophysica acta - 1 Feb 2009

Bernal José Antonio, Mulet José, Castillo Mar, Criado Manuel, Sala Salvador, Sala Francisco

Abstract excerpt

The highly conserved alphaLys145 has been suggested to play an important role in the early steps of activation of the nicotinic acetylcholine receptor (nAChR) by acetylcholine. Both macroscopic and single channel currents were recorded in the slowly desensitizing mutants L248T- and K145A-L248T-alpha7 receptors expressed in Xenopus oocytes. On ACh-evoked currents, substitution of Lys145 by alanine showed the same...

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Source

Identifiers

PMID: 19063861
DOI: 10.1016/j.bbamem.2008.11.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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