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Article

Single-channel and structural foundations of neuronal α7 acetylcholine receptor potentiation.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 28 Sept 2011

daCosta Corrie J B, Free Chris R, Corradi Jeremías, Bouzat Cecilia, Sine Steven M

Abstract excerpt

Potentiation of neuronal nicotinic acetylcholine receptors by exogenous ligands is a promising strategy for treatment of neurological disorders including Alzheimer's disease and schizophrenia. To gain insight into molecular mechanisms underlying potentiation, we examined ACh-induced single-channel currents through the human neuronal α7 acetylcholine receptor in the presence of the α7-specific potentiator...

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Identifiers

PMID: 21957249
DOI: 10.1523/JNEUROSCI.2652-11.2011
PMCID: PMC3226716

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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