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Article

Role of the extracellular transmembrane domain interface in gating and pharmacology of a heteromeric neuronal nicotinic receptor.

Journal of neurochemistry - 1 May 2010

Aldea Marcos, Castillo Mar, Mulet José, Sala Salvador, Criado Manuel, Sala Francisco

Abstract excerpt

Nicotinic acetylcholine receptors (nAChRs) transmit the agonist signal to the channel gate through a number of extracellular domains. We have previously shown that particular details of the process of coupling binding to gating could be quantitative and qualitatively different in muscle and neuronal type nAChRs. We have extended previous studies on homomeric alpha7 nAChRs to heteromeric alpha3beta4 nAChRs, by...

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Source

Identifiers

PMID: 20420581
DOI: 10.1111/j.1471-4159.2010.06665.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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