Effects of translation initiation factor eIF-5A on the functioning of human T-cell leukemia virus type I Rex and human immunodeficiency virus Rev inhibited trans dominantly by a Rex mutant deficient in RNA binding.

doi:10.1128/JVI.69.5.3125-3133.1995

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Article

Effects of translation initiation factor eIF-5A on the functioning of human T-cell leukemia virus type I Rex and human immunodeficiency virus Rev inhibited trans dominantly by a Rex mutant deficient in RNA binding.

Journal of virology - 1 May 1995

Katahira J, Ishizaki T, Sakai H, Adachi A, Yamamoto K, Shida H

Abstract excerpt

The viral transactivator proteins Rex and Rev are necessary for the expression of structural proteins of human T-cell leukemia virus type I and human immunodeficiency virus type 1, respectively. Although the interaction of Rex/Rev with a cellular cofactor(s) has been thought to be required for Rex/Rev action, there is no suitable system to search for the cofactor(s) in mammalian cells. We found that a Rex mutant,...

Topics

Animals
Base Sequence
Cell Line
DNA Primers
DNA, Viral
Gene Products, rev
Gene Products, rex
Genes, Dominant
HIV-1
Human T-lymphotropic virus 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Molecular Sequence Data

Mutation

Peptide Initiation Factors

RNA, Viral

RNA-Binding Proteins

rev Gene Products, Human Immunodeficiency Virus

Eukaryotic Translation Initiation Factor 5A

Source

Open in PubMed Open full text

Identifiers

PMID: 7707541
DOI: 10.1128/JVI.69.5.3125-3133.1995
PMCID: PMC189014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7707541-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Effects of translation initiation factor eIF-5A on the functioning of human T-cell leukemia virus type I Rex and human immunodeficiency virus Rev inhibited trans dominantly by a Rex mutant deficient in RNA binding.PMID 7707541Read ↗

The type I human T-cell leukemia virus (HTLV-I) Rex trans-activator binds directly to the HTLV-I Rex and the type 1 human immunodeficiency virus Rev RNA response elements.Semantic proximity Read ↗

Transdominant repressors for human T-cell leukemia virus type I rex and human immunodeficiency virus type 1 rev function.Semantic proximity Read ↗

Dominant-negative mutants are clustered in a domain of the human T-cell leukemia virus type I Rex protein: implications for trans dominance.Semantic proximity Read ↗

Modulation of HTLV-I gene expression by HIV-1 Rev through an alternative RxRE-independent pathway mediated by the RU5 portion of the 5'-LTR.Semantic proximity Read ↗

Multiple arginine residues within the basic domain of HTLV-I Rex are required for specific RNA binding and function.Semantic proximity Read ↗

Titration of cellular export factors, but not heteromultimerization, is the molecular mechanism of trans-dominant HTLV-1 rex mutants.Semantic proximity Read ↗

Effects of chimeric mutants of human immunodeficiency virus type 1 Rev and human T-cell leukemia virus type I Rex on nucleolar targeting signals.Semantic proximity Read ↗

Binding of trans-dominant mutant Rev protein of human immunodeficiency virus type 1 to the cis-acting Rev-responsive element does not affect the fate of viral mRNA.Semantic proximity Read ↗

Multimer formation is not essential for nuclear export of human T-cell leukemia virus type 1 Rex trans-activator protein.Semantic proximity Read ↗

Dominant negative mutants of human T-cell leukemia virus type I Rex and human immunodeficiency virus type 1 Rev fail to multimerize in vivo.Semantic proximity Read ↗

Identification of a novel cellular cofactor for the Rev/Rex class of retroviral regulatory proteins.Semantic proximity Read ↗

Formation of trans-activation competent HIV-1 Rev:RRE complexes requires the recruitment of multiple protein activation domains.Semantic proximity Read ↗

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