Article
UNC-51/ATG1 kinase regulates axonal transport by mediating motor-cargo assembly.
Genes & development - 1 Dec 2008
Toda Hirofumi, Mochizuki Hiroaki, Flores Rafael, Josowitz Rebecca, Krasieva Tatiana B, Lamorte Vickie J, Suzuki Emiko, Gindhart Joseph G, Furukubo-Tokunaga Katsuo, Tomoda Toshifumi
Abstract excerpt
Axonal transport mediated by microtubule-dependent motors is vital for neuronal function and viability. Selective sets of cargoes, including macromolecules and organelles, are transported long range along axons to specific destinations. Despite intensive studies focusing on the motor machinery, the regulatory mechanisms that control motor-cargo assembly are not well understood. Here we show that UNC-51/ATG1...
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