Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phosphorylation of FEZ1 by Microtubule Affinity Regulating Kinases regulates its function in presynaptic protein trafficking.

Scientific reports - 1 Jun 2016

Butkevich Eugenia, Härtig Wolfgang, Nikolov Miroslav, Erck Christian, Grosche Jens, Urlaub Henning, Schmidt Christoph F, Klopfenstein Dieter R, Chua John Jia En

Abstract excerpt

Adapters bind motor proteins to cargoes and therefore play essential roles in Kinesin-1 mediated intracellular transport. The regulatory mechanisms governing adapter functions and the spectrum of cargoes recognized by individual adapters remain poorly defined. Here, we show that cargoes transported by the Kinesin-1 adapter FEZ1 are enriched for presynaptic components and identify that specific phosphorylation of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to Axonal Transport

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Caenorhabditis elegans Proteins

Share to Cerebral Cortex

Share to Hippocampus

Share to Kinesins

Share to Synaptic Transmission

Share to Synaptic Vesicles

Source

Open in PubMed Open full text

Identifiers

PMID: 27247180
DOI: 10.1038/srep26965
PMCID: PMC4887895

Genes

FEZ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phosphorylation of FEZ1 by Microtubule Affinity Regulating Kinases regulates its function in presynaptic protein trafficking.PMID 27247180Read ↗

Phosphorylation-regulated axonal dependent transport of syntaxin 1 is mediated by a Kinesin-1 adapter.Semantic proximity Read ↗

Traffic Jams in the Brain: How Kinesin Dysfunction Shapes Neurodevelopmental DisordersSemantic proximity Read ↗

CDKL5’s role in microtubule-based transport and cognitive functionSemantic proximity Read ↗

Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear importSemantic proximity Read ↗

The GRIP1/14-3-3 pathway coordinates cargo trafficking and dendrite development.Semantic proximity Read ↗

RIM1α SUMOylation is required for fast synaptic vesicle exocytosis.Semantic proximity Read ↗

KIF5A binds RNA to orchestrate synaptic mRNA localization and stress granules in ALSSemantic proximity Read ↗

New synaptic bouton formation is disrupted by misregulation of microtubule stability in aPKC mutants.Semantic proximity Read ↗

Delineation of the TRAK binding regions of the kinesin-1 motor proteins.Semantic proximity Read ↗

Regulation of KIF1A-Driven Dense Core Vesicle Transport: Ca2+/CaM Controls DCV Binding and Liprin-α/TANC2 Recruits DCVs to Postsynaptic Sites.Semantic proximity Read ↗

Proteomic characterization of the Alzheimer’s disease risk factor BIN1 interactomeSemantic proximity Read ↗

PI31 is an adaptor protein for proteasome transport in axons and required for synaptic development and functionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.