Article
PI31 is an adaptor protein for proteasome transport in axons and required for synaptic development and function
2018-07-07
Abstract excerpt
Protein degradation by the ubiquitin-proteasome system (UPS) is critical for neuronal development, plasticity and function. Neurons utilize microtubule-dependent molecular motors to allocate proteasomes to synapses, but how proteasomes are coupled to motor proteins and how this transport is regulated to meet changing demand for protein breakdown remains largely unknown. We show that the conserved proteasome-bindin...
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Identifiers and source
- Literature Corpus work
- 7f5c2d4b-0bff-5e02-a893-5224394ac71a
- DOI
- 10.1101/364463