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Article

Neuronal Activity and CaMKII Regulate Kinesin-Mediated Transport of Synaptic AMPARs.

Neuron - 22 Apr 2015

Hoerndli Frédéric J, Wang Rui, Mellem Jerry E, Kallarackal Angy, Brockie Penelope J, Thacker Colin, Madsen David M, Maricq Andres V

Abstract excerpt

Excitatory glutamatergic synaptic transmission is critically dependent on maintaining an optimal number of postsynaptic AMPA receptors (AMPARs) at each synapse of a given neuron. Here, we show that presynaptic activity, postsynaptic potential, voltage-gated calcium channels (VGCCs) and UNC-43, the C. elegans homolog of CaMKII, control synaptic strength by regulating motor-driven AMPAR transport. Genetic mutations...

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Identifiers

PMID: 25843407
DOI: 10.1016/j.neuron.2015.03.011
PMCID: PMC4409548

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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