Article
Unc-51/ATG1 controls axonal and dendritic development via kinesin-mediated vesicle transport in the Drosophila brain.
PloS one - 12 May 2011
Mochizuki Hiroaki, Toda Hirofumi, Ando Mai, Kurusu Mitsuhiko, Tomoda Toshifumi, Furukubo-Tokunaga Katsuo
Abstract excerpt
BACKGROUND: Members of the evolutionary conserved Ser/Thr kinase Unc-51 family are key regulatory proteins that control neural development in both vertebrates and invertebrates. Previous studies have suggested diverse functions for the Unc-51 protein, including axonal elongation, growth cone guidance, and synaptic vesicle transport. METHODOLOGY/PRINCIPAL FINDINGS: In this work, we have investigated the functional...
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