Article
Stwl modifies chromatin compaction and is required to maintain DNA integrity in the presence of perturbed DNA replication.
Molecular biology of the cell - 1 Feb 2009
Yi Xia, de Vries Hilda I, Siudeja Katarzyna, Rana Anil, Lemstra Willy, Brunsting Jeanette F, Kok Rob M, Smulders Yvo M, Schaefer Matthias, Dijk Freark, Shang Yongfeng, Eggen Bart J L, Kampinga Harm H, Sibon Ody C M
Abstract excerpt
Hydroxyurea, a well-known DNA replication inhibitor, induces cell cycle arrest and intact checkpoint functions are required to survive DNA replication stress induced by this genotoxic agent. Perturbed DNA synthesis also results in elevated levels of DNA damage. It is unclear how organisms prevent accumulation of this type of DNA damage that coincides with hampered DNA synthesis. Here, we report the identification...
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