Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genomic mapping of single-stranded DNA in hydroxyurea-challenged yeasts identifies origins of replication.

Nature cell biology - 1 Feb 2006

Feng Wenyi, Collingwood David, Boeck Max E, Fox Lindsay A, Alvino Gina M, Fangman Walton L, Raghuraman Mosur K, Brewer Bonita J

Abstract excerpt

During DNA replication one or both strands transiently become single stranded: first at the sites where initiation of DNA synthesis occurs (known as origins of replication) and subsequently on the lagging strands of replication forks as discontinuous Okazaki fragments are generated. We report a genome-wide analysis of single-stranded DNA (ssDNA) formation in the presence of hydroxyurea during DNA replication in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Checkpoint Kinase 2
Share to DNA, Single-Stranded

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Exodeoxyribonucleases

Share to Genome, Fungal

Share to Hydroxyurea

Share to Replication Origin

Share to S Phase

Share to Yeasts

Source

Open in PubMed Open full text

Identifiers

PMID: 16429127
DOI: 10.1038/ncb1358
PMCID: PMC1414058

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genomic mapping of single-stranded DNA in hydroxyurea-challenged yeasts identifies origins of replication.PMID 16429127Read ↗

Exceptional origin activation revealed by comparative analysis in two laboratory yeast strains.Semantic proximity Read ↗

Improved short nascent strand sequencing (iSNS-seq) enhances DNA replication origin detection and reduces non-origin biasesSemantic proximity Read ↗

Monitoring S phase progression globally and locally using BrdU incorporation in TK(+) yeast strains.Semantic proximity Read ↗

Genome-wide replication profiles of S-phase checkpoint mutants reveal fragile sites in yeast.Semantic proximity Read ↗

Checkpoint independence of most DNA replication origins in fission yeast.Semantic proximity Read ↗

Cdc45 protein-single-stranded DNA interaction is important for stalling the helicase during replication stress.Semantic proximity Read ↗

Budding yeast Rif1 binds to replication origins and protects DNA at blocked replication forks.Semantic proximity Read ↗

High-resolution mapping, characterization, and optimization of autonomously replicating sequences in yeast.Semantic proximity Read ↗

S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex.Semantic proximity Read ↗

Limiting DNA polymerase delta alters replication dynamics and leads to a dependence on checkpoint activation and recombination-mediated DNA repairSemantic proximity Read ↗

Yeast Stn1 promotes MCM to circumvent Rad53 control of the S phase checkpoint.Semantic proximity Read ↗

Continued DNA synthesis in replication checkpoint mutants leads to fork collapse.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.