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Article

Nucleostemin deletion reveals an essential mechanism that maintains the genomic stability of stem and progenitor cells.

Proceedings of the National Academy of Sciences of the United States of America - 9 Jul 2013

Meng Lingjun, Lin Tao, Peng Guang, Hsu Joseph K, Lee Sun, Lin Shiaw-Yih, Tsai Robert Y L

Abstract excerpt

Stem and progenitor cells maintain a robust DNA replication program during the tissue expansion phase of embryogenesis. The unique mechanism that protects them from the increased risk of replication-induced DNA damage, and hence permits self-renewal, remains unclear. To determine whether the genome integrity of stem/progenitor cells is safeguarded by mechanisms involving molecules beyond the core DNA repair...

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Identifiers

PMID: 23798389
DOI: 10.1073/pnas.1301672110
PMCID: PMC3710807

Genes

RAD51

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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