Article
Association of MTHFR C677T, MTHFRA1298C, and MTRRA66G Gene Polymorphisms with Hyperhomocysteinemia and Its Modulation by the Combined Effect of Vitamin B12 and Folate in Chinese Population with Hypertension.
The Journal of nutrition - 1 Apr 2025
Siddiqi Sultan Mehmood, Liu Lishun, Du Yiming, Song Yun, Chen Ping, Li Shuqun, He Qiangqiang, Zhou Ziyi, Xu Jiafeng, Bai Jie, Wang Binyan, Qin Xianhui, Mehmood Anam, Xiuqing Liu, Cheng Xiaoxu, Shi Han-Ping
Abstract excerpt
BACKGROUND: In China, the MTHFR 677T allele, unlike in most Western populations, is a rare genetic variant linked to various disorders. The contributing nutritional and genetic factors to this genetic risk remain unclear. OBJECTIVE: This study aimed to elucidate the interactions between genetic variations in total homocysteine (tHcy) pathway genes, serum tHcy concentrations, and nutritional factors in a Chinese...
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