Article
Loss of SUFU function in familial multiple meningioma.
American journal of human genetics - 7 Sept 2012
Aavikko Mervi, Li Song-Ping, Saarinen Silva, Alhopuro Pia, Kaasinen Eevi, Morgunova Ekaterina, Li Yilong, Vesanen Kari, Smith Miriam J, Evans D Gareth R, Pöyhönen Minna, Kiuru Anne, Auvinen Anssi, Aaltonen Lauri A, Taipale Jussi, Vahteristo Pia
Abstract excerpt
Meningiomas are the most common primary tumors of the CNS and account for up to 30% of all CNS tumors. An increased risk of meningiomas has been associated with certain tumor-susceptibility syndromes, especially neurofibromatosis type II, but no gene defects predisposing to isolated familial meningiomas have thus far been identified. Here, we report on a family of five meningioma-affected siblings, four of whom...
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