Article
COMT Val158Met polymorphism in relation to activation and de-activation in the prefrontal cortex: A study in patients with schizophrenia and healthy subjects.
NeuroImage - 15 Nov 2010
Pomarol-Clotet E, Fatjó-Vilas M, McKenna P J, Monté G C, Sarró S, Ortiz-Gil J, Aguirre C, Gomar J J, Guerrero A, Landin R, Capdevila A, Fañanás L, Salvador R
Abstract excerpt
The Val158Met polymorphism in the COMT gene has been found to be associated with differences in brain activation in both healthy subjects and patients with schizophrenia. The predominant finding has been increased prefrontal activation associated with the Val allele; however, genotype-related de-activations have not been studied. In this study 42 schizophrenia patients and 31 controls underwent fMRI while...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.