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Article

Irritable bowel syndrome: methods, mechanisms, and pathophysiology. Genetic epidemiology and pharmacogenetics in irritable bowel syndrome.

American journal of physiology. Gastrointestinal and liver physiology - 15 May 2012

Camilleri Michael, Katzka David A

Abstract excerpt

The objectives of this review are twofold. Our first objective is to evaluate the evidence supporting a role for genetics in irritable bowel syndrome (IBS). Specific examples of the associations of genetic variation and symptoms, syndromes, and intermediate phenotypes, including neurotransmitter (serotonergic, α(2)-adrenergic, and cannabinoid) mechanisms, inflammatory pathways (IL-10, TNFα, GNβ3, and...

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Bile Acids and Salts
Cytokines
Gene Frequency
Genetic Loci
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Irritable Bowel Syndrome

Polymorphism, Genetic

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Identifiers

PMID: 22403795
DOI: 10.1152/ajpgi.00537.2011
PMCID: PMC3362100

Genes

CNR1
FAAH
FGFR4
KLB
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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