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Article

Genetic variation in endocannabinoid metabolism, gastrointestinal motility, and sensation.

American journal of physiology. Gastrointestinal and liver physiology - 1 Jan 2008

Camilleri Michael, Carlson Paula, McKinzie Sanna, Grudell April, Busciglio Irene, Burton Duane, Baxter Kari, Ryks Michael, Zinsmeister Alan R

Abstract excerpt

Cannabinoid agonist inhibits gastrointestinal motility. The endocannabinoid, anandamide, is inactivated by fatty acid amide hydrolase (FAAH). A single nucleotide polymorphism in the human FAAH gene (C385A) reduces FAAH expression. Our aim was to evaluate associations between FAAH genotype variation and symptom phenotype, gastric emptying and volume, colonic transit, and rectal sensation in patients with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17962356
DOI: 10.1152/ajpgi.00371.2007

Genes

FAAH

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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