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Article

Farnesoid X receptor (FXR) activation and FXR genetic variation in inflammatory bowel disease.

PloS one - 1 Jan 2011

Nijmeijer Rian M, Gadaleta Raffaella M, van Mil Saskia W C, van Bodegraven Adriaan A, Crusius J Bart A, Dijkstra Gerard, Hommes Daan W, de Jong Dirk J, Stokkers Pieter C F, Verspaget Hein W, Weersma Rinse K, van der Woude C Janneke, Stapelbroek Janneke M, Schipper Marguerite E I, Wijmenga Cisca, van Erpecum Karel J, Oldenburg Bas

Abstract excerpt

BACKGROUND: We previously showed that activation of the bile salt nuclear receptor Farnesoid X Receptor (FXR) protects against intestinal inflammation in mice. Reciprocally, these inflammatory mediators may decrease FXR activation. We investigated whether FXR activation is repressed in the ileum...

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Identifiers

PMID: 21887309
DOI: 10.1371/journal.pone.0023745
PMCID: PMC3161760

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21887309-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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