Article
Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and population-based sample.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 May 2009
Zuo Lingjun, Kranzler Henry R, Luo Xingguang, Yang Bao-zhu, Weiss Roger, Brady Kathleen, Poling James, Farrer Lindsay, Gelernter Joel
Abstract excerpt
We recently reported that, in a European-American (EA) sample, the interaction between two cannabinoid receptor 1 gene (CNR1) variants significantly increased risk for drug dependence (DD), including cocaine dependence (CD). This study aimed to investigate directly the association between CNR1 and CD in four independent samples. Eight markers across the 45 kb CNR1 region and four large samples, ie, family-based...
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