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Article

Further evidence for association of polymorphisms in the CNR1 gene with cocaine addiction: confirmation in an independent sample and meta-analysis.

Addiction biology - 1 Jul 2013

Clarke Toni-Kim, Bloch Paul J, Ambrose-Lanci Lisa M, Ferraro Thomas N, Berrettini Wade H, Kampman Kyle M, Dackis Charles A, Pettinati Helen M, O'Brien Charles P, Oslin David W, Lohoff Falk W

Abstract excerpt

Genetic research on cocaine dependence (CD) may help clarify our understanding of the disorder as well as provide insights for effective treatment. As endocannabinoid signaling and dopamine neurotransmission have been shown to be involved in drug reward, genes related to these systems are plausible candidates for susceptibility to CD. The cannabinoid receptor 1 protein regulates both the endocannabinoid and...

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Source

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Identifiers

PMID: 21790903
DOI: 10.1111/j.1369-1600.2011.00346.x
PMCID: PMC3223560

Genes

CNR1

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Related research

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Further evidence for association of polymorphisms in the CNR1 gene with cocaine addiction: confirmation in an independent sample and meta-analysis.PMID 21790903Read ↗

Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and population-based sample.Semantic proximity Read ↗

CNR1 gene polymorphisms in addictive disorders: a systematic review and a meta-analysis.Semantic proximity Read ↗

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Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence.Semantic proximity Read ↗

Association study of the CNR1 gene exon 3 alternative promoter region polymorphisms and substance dependence.Semantic proximity Read ↗

Association of a polymorphism in the Homer1 gene with cocaine dependence in an African American population.Semantic proximity Read ↗

The association between cannabinoid receptor 1 gene (CNR1) and cannabis dependence symptoms in adolescents and young adults.Semantic proximity Read ↗

A delta-opioid receptor genetic variant is associated with abstinence prior to and during cocaine dependence treatment.Semantic proximity Read ↗

Cannabinoid receptor 1 gene association with nicotine dependence.Semantic proximity Read ↗

CNR1 variation modulates risk for drug and alcohol dependence.Semantic proximity Read ↗

Overlapping dopaminergic pathway genetic susceptibility to heroin and cocaine addictions in African Americans.Semantic proximity Read ↗

Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts.Semantic proximity Read ↗

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