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Article

Genetic Architecture and Molecular Neuropathology of Human Cocaine Addiction.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Jul 2020

Huggett Spencer B, Stallings Michael C

Abstract excerpt

We integrated genomic and bioinformatic analyses, using data from the largest genome-wide association study of cocaine dependence (CD; n = 6546; 82.37% with CD; 57.39% male) and the largest postmortem gene-expression sample of individuals with cocaine use disorder (CUD; n = 36; 51.35% with CUD; 100% male). Our genome-wide analyses identified one novel gene (NDUFB9) associated with the genetic predisposition to CD...

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Identifiers

PMID: 32457073
DOI: 10.1523/JNEUROSCI.2879-19.2020
PMCID: PMC7329314

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