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Article

Overlapping dopaminergic pathway genetic susceptibility to heroin and cocaine addictions in African Americans.

Annals of human genetics - 1 May 2015

Levran Orna, Randesi Matthew, da Rosa Joel Correa, Ott Jurg, Rotrosen John, Adelson Miriam, Kreek Mary Jeanne

Abstract excerpt

Drugs of abuse activate the mesolimbic dopaminergic pathway. Genetic variations in the dopaminergic system may contribute to drug addiction. Several processes are shared between cocaine and heroin addictions but some neurobiological mechanisms may be specific. This study examined the association of 98 single nucleotide polymorphisms in 13 dopamine-related genes with heroin addiction (OD) and/or cocaine addiction...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 25875614
DOI: 10.1111/ahg.12104
PMCID: PMC4399004

Genes

COMT
DRD1
DRD2
DBH
DDC
DRD3
DRD5

Variants

rs1075650
rs1075650

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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