Article

RGS14 is neuroprotective against seizure-induced mitochondrial oxidative stress and pathology in hippocampus

2023-02-03

Abstract excerpt

RGS14 is a complex multifunctional scaffolding protein that is highly enriched within pyramidal cells (PCs) of hippocampal area CA2. There, RGS14 suppresses glutamate-induced calcium influx and related G protein and ERK signaling in dendritic spines to restrain postsynaptic signaling and plasticity. Previous findings show that, unlike PCs of hippocampal areas CA1 and CA3, CA2 PCs are resistant to a number of neuro...

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Literature Corpus work: 418f73a8-6fe5-5d94-9904-da084ba1bc77
DOI: 10.1101/2023.02.01.526349

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