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Article

Pumilio2-deficient mice show a predisposition for epilepsy.

Disease models & mechanisms - 1 Nov 2017

Follwaczny Philipp, Schieweck Rico, Riedemann Therese, Demleitner Antonia, Straub Tobias, Klemm Anna H, Bilban Martin, Sutor Bernd, Popper Bastian, Kiebler Michael A

Abstract excerpt

Epilepsy is a neurological disease that is caused by abnormal hypersynchronous activities of neuronal ensembles leading to recurrent and spontaneous seizures in human patients. Enhanced neuronal excitability and a high level of synchrony between neurons seem to trigger these spontaneous seizures. The molecular mechanisms, however, regarding the development of neuronal hyperexcitability and maintenance of epilepsy...

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Source

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Identifiers

PMID: 29046322
DOI: 10.1242/dmm.029678
PMCID: PMC5719250

Genes

GABRA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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