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Article

Transcriptional upregulation of Cav3.2 mediates epileptogenesis in the pilocarpine model of epilepsy.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 3 Dec 2008

Becker Albert J, Pitsch Julika, Sochivko Dmitry, Opitz Thoralf, Staniek Matthäus, Chen Chien-Chang, Campbell Kevin P, Schoch Susanne, Yaari Yoel, Beck Heinz

Abstract excerpt

In both humans and animals, an insult to the brain can lead, after a variable latent period, to the appearance of spontaneous epileptic seizures that persist for life. The underlying processes, collectively referred to as epileptogenesis, include multiple structural and functional neuronal alterations. We have identified the T-type Ca(2+) channel Ca(v)3.2 as a central player in epileptogenesis. We show that a...

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Source

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Identifiers

PMID: 19052226
DOI: 10.1523/JNEUROSCI.1421-08.2008
PMCID: PMC6671595

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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