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Article

IGF2 knockout mice are resistant to kainic acid-induced seizures and neurodegeneration.

Brain research - 17 Oct 2007

Dikkes Pieter, B Jaffe David, Guo Wei-Hui, Chao Christina, Hemond Peter, Yoon Kihoon, Zurakowski David, Lopez Mary Frances

Abstract excerpt

Insulin-like growth factor 2 (Igf2), a member of the insulin gene family, is important for brain development and has known neurotrophic properties. Though Igf2, its receptors, and binding proteins, are expressed in the adult CNS, their role in the adult brain is less well-understood. Here we studied how Igf2 deficiency affects brains of adult Igf2 knockout (Igf2(-/-)) mice following neurotoxic insult produced by...

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Source

Identifiers

PMID: 17870057
DOI: 10.1016/j.brainres.2007.05.068

Genes

IGF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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