Article

Cell membrane proteome profiling uncovers molecular signatures and GPCR regulators underlying diet-induced obesity and exercise-mediated adaptation

2026-04-27

Abstract excerpt

Cell membrane proteins (CMPs), notably G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs), represent the largest class of druggable targets. Despite their therapeutic importance, how the CMP landscape is systemically remodeled during metabolic disease progression and in response to exercise remains poorly understood. Here, we constructed the most comprehensive CMP proteome atlas to date acros...

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Literature Corpus work: 4e9caef3-2405-5665-b437-6845d3028875
DOI: 10.64898/2026.04.23.720492

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