The rs2274911 polymorphism in GPRC6A gene is associated with insulin resistance in normal weight and obese subjects.

doi:10.1111/cen.13248

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Article

The rs2274911 polymorphism in GPRC6A gene is associated with insulin resistance in normal weight and obese subjects.

Clinical endocrinology - 1 Feb 2017

Di Nisio Andrea, Rocca Maria Santa, Fadini Gian Paolo, De Toni Luca, Marcuzzo Giorgio, Marescotti Maria Cristina, Sanna Marta, Plebani Mario, Vettor Roberto, Avogaro Angelo, Foresta Carlo

Abstract excerpt

OBJECTIVE: Identification of the novel endocrine role of osteocalcin (OC) and its receptor GPRC6A has given rise to a new branch of research in OC/GPRC6A axis related to glucose metabolism. GPRC6A- and OC-deficient mice share features of the metabolic syndrome, in addition to male infertility. Recently, the polymorphism rs2274911 in GPRC6A was shown to be associated with testicular impairment. We aimed to...

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PMID: 27696500
DOI: 10.1111/cen.13248

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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