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Article

The KCNMB1 E65K variant is associated with reduced central pulse pressure in the community-based Framingham Offspring Cohort.

Journal of hypertension - 1 Jan 2009

Kelley-Hedgepeth Alyson, Peter Inga, Montefusco Maria Claudia, Levy Daniel, Benjamin Emelia J, Vasan Ramachandran S, Mendelsohn Michael E, Housman David, Huggins Gordon S, Mitchell Gary F

Abstract excerpt

OBJECTIVES: Genetic variants that influence large conductance calcium-activated potassium channel's function may alter arterial function and contribute to the known heritability of arterial stiffness and blood pressure. The beta1-subunit (KCNMB1) of the large conductance calcium-activated potassium channel includes two coding region polymorphisms. E65K, a gain-of-function polymorphism, is predicted to enhance...

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Identifiers

PMID: 19050450
DOI: 10.1097/HJH.0b013e328317c8ae
PMCID: PMC2637763

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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