Article
The KCNMB1 Glu65Lys polymorphism associates with reduced systolic and diastolic blood pressure in the Inter99 study of 5729 Danes.
Journal of hypertension - 1 Nov 2008
Nielsen Trine, Burgdorf Kristoffer Sølvsten, Grarup Niels, Borch-Johnsen Knut, Hansen Torben, Jørgensen Torben, Pedersen Oluf, Andersen Gitte
Abstract excerpt
OBJECTIVE: The large Ca2+ and voltage-dependent potassium channel is important in regulating vascular tone in smooth muscle tissue. The rs11739136 KCNMB1 Glu65Lys polymorphism in the beta1 subunit of the Ca2+ and voltage-dependent potassium channel has, in some studies, been reported to associate with a protective effect on diastolic hypertension. The previous studies have, however, been conflicting, and the aim...
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