Article
Common genetic variation in the 3'-BCL11B gene desert is associated with carotid-femoral pulse wave velocity and excess cardiovascular disease risk: the AortaGen Consortium.
Circulation. Cardiovascular genetics - 1 Feb 2012
Mitchell Gary F, Verwoert Germaine C, Tarasov Kirill V, Isaacs Aaron, Smith Albert V, Yasmin, Rietzschel Ernst R, Tanaka Toshiko, Liu Yongmei, Parsa Afshin, Najjar Samer S, O'Shaughnessy Kevin M, Sigurdsson Sigurdur, De Buyzere Marc L, Larson Martin G, Sie Mark P S, Andrews Jeanette S, Post Wendy S, Mattace-Raso Francesco U S, McEniery Carmel M, Eiriksdottir Gudny, Segers Patrick, Vasan Ramachandran S, van Rijn Marie Josee E, Howard Timothy D, McArdle Patrick F, Dehghan Abbas, Jewell Elizabeth S, Newhouse Stephen J, Bekaert Sofie, Hamburg Naomi M, Newman Anne B, Hofman Albert, Scuteri Angelo, De Bacquer Dirk, Ikram Mohammad Arfan, Psaty Bruce M, Fuchsberger Christian, Olden Matthias, Wain Louise V, Elliott Paul, Smith Nicholas L, Felix Janine F, Erdmann Jeanette, Vita Joseph A, Sutton-Tyrrell Kim, Sijbrands Eric J G, Sanna Serena, Launer Lenore J, De Meyer Tim, Johnson Andrew D, Schut Anna F C, Herrington David M, Rivadeneira Fernando, Uda Manuela, Wilkinson Ian B, Aspelund Thor, Gillebert Thierry C, Van Bortel Luc, Benjamin Emelia J, Oostra Ben A, Ding Jingzhong, Gibson Quince, Uitterlinden André G, Abecasis Gonçalo R, Cockcroft John R, Gudnason Vilmundur, De Backer Guy G, Ferrucci Luigi, Harris Tamara B, Shuldiner Alan R, van Duijn Cornelia M, Levy Daniel, Lakatta Edward G, Witteman Jacqueline C M
Abstract excerpt
BACKGROUND: Carotid-femoral pulse wave velocity (CFPWV) is a heritable measure of aortic stiffness that is strongly associated with increased risk for major cardiovascular disease events. METHODS AND RESULTS: We conducted a meta-analysis of genome-wide association data in 9 community-based European ancestry cohorts consisting of 20 634 participants. Results were replicated in 2 additional European ancestry...
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