Article
Common charge-shift mutation Glu65Lys in K+ channel β₁-Subunit KCNMB1: pleiotropic consequences for glomerular filtration rate and progressive renal disease.
American journal of nephrology - 1 Jan 2010
Chen Yuqing, Salem Rany M, Rao Fangwen, Fung Maple M, Bhatnagar Vibha, Pandey Braj, Mahata Manjula, Waalen Jill, Nievergelt Caroline M, Lipkowitz Michael S, Hamilton Bruce A, Mahata Sushil K, O'Connor Daniel T
Abstract excerpt
BACKGROUND: Glomerular filtration rate (GFR) is a heritable trait, and hyperfiltration (GFR increment in remnant nephrons) may accelerate renal functional decline in chronic kidney disease (CKD). Mesangial and vascular smooth myocytes control GFR by contraction, dependent on voltage-gated Ca(2+) influx, which is controlled by the regulatory β₁-subunit (KCNMB1) of large-conductance heteromeric K+ ('BK') channels....
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