Article
Vascular stiffness and genetic variation at the endothelial nitric oxide synthase locus: the Framingham Heart study.
Hypertension (Dallas, Tex. : 1979) - 1 Jun 2007
Mitchell Gary F, Guo Chao-Yu, Kathiresan Sekar, Vasan Ramachandran S, Larson Martin G, Vita Joseph A, Keyes Michelle J, Vyas Mitul, Newton-Cheh Christopher, Musone Stacy L, Camargo Amy L, Drake Jared A, Levy Daniel, O'Donnell Christopher J, Hirschhorn Joel N, Benjamin Emelia J
Abstract excerpt
Arterial stiffness is a moderately heritable trait that is affected by alterations in the bioavailability of NO. Previous studies have found associations between variants in the gene for endothelial NO synthase (NOS3) and arterial properties. We previously identified a linkage peak for forward pressure wave amplitude in the immediate vicinity of NOS3. Therefore, we evaluated relations between arterial stiffness...
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