Article
Gain-of-function mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertension.
The Journal of clinical investigation - 1 Apr 2004
Fernández-Fernández José M, Tomás Marta, Vázquez Esther, Orio Patricio, Latorre Ramón, Sentí Mariano, Marrugat Jaume, Valverde Miguel A
Abstract excerpt
Hypertension is the most prevalent risk factor for cardiovascular diseases, present in almost 30% of adults. A key element in the control of vascular tone is the large-conductance, Ca(2+)-dependent K(+) (BK) channel. The BK channel in vascular smooth muscle is formed by an ion-conducting alpha subunit and a regulatory beta(1) subunit, which couples local increases in intracellular Ca(2+) to augmented channel...
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