Article
Variant HNF1 modulates epithelial plasticity of normal and transformed ovary cells.
Neoplasia (New York, N.Y.) - 1 Dec 2008
Tomassetti Antonella, De Santis Giuseppina, Castellano Giancarlo, Miotti Silvia, Mazzi Mimma, Tomasoni Daniela, Van Roy Frans, Carcangiu Maria Luisa, Canevari Silvana
Abstract excerpt
Ovarian carcinoma arises from the ovarian surface epithelium, which undergoes phenotypic changes characteristic of müllerian epithelium during the first stages of tumorigenesis. The variant isoform of the hepatocyte nuclear factor 1 (vHNF1) is a transcription factor involved in the development of tissues derived from the müllerian duct. Here, we show that vHNF1 knockdown in two ovarian carcinoma cell lines, SKOV3...
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