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The identification of nuclear αvβ3 integrin in ovarian cancer: non-paradigmal localization with cancer promoting actions

29 Jul 2020

Abstract excerpt

Nuclear translocation of transmembrane proteins was reported in high-grade serous ovarian cancer (HGSOC), a highly aggressive gynecological malignancy. Although the membrane receptor αvβ3 integrin is amply expressed in HGSOC and involved in disease progression, its nuclear localization was never demonstrated. Nuclear αvβ3 was explored in HGSOC cells (OVCAR3, KURAMOCHI, and JHOS4), nuclear localization signal...

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PMID: 32728020
DOI: 10.1038/s41389-020-00254-2

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