Article
HNF1α inhibition triggers epithelial-mesenchymal transition in human liver cancer cell lines.
BMC cancer - 5 Oct 2011
Pelletier Laura, Rebouissou Sandra, Vignjevic Danijela, Bioulac-Sage Paulette, Zucman-Rossi Jessica
Abstract excerpt
BACKGROUND: Hepatocyte Nuclear Factor 1α (HNF1α) is an atypical homeodomain-containing transcription factor that transactivates liver-specific genes including albumin, α-1-antitrypsin and α- and β-fibrinogen. Biallelic inactivating mutations of HNF1A have been frequently identified in hepatocellular adenomas (HCA), rare benign liver tumors usually developed in women under oral contraceptives, and in rare cases of...
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