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Upregulation of fibronectin following loss of p53 function is a poor prognostic factor in ovarian carcinoma with a unique immunophenotype

2020-03-31

Abstract excerpt

<h4>Background: </h4> We previously demonstrated that ovarian high grade serous carcinomas (OHGSeCa) and ovarian clear cell carcinomas (OCCCa) with an HNF-1β+/p53+/ARID1A+ immunophenotype were associated with the worst unfavorable prognosis. To clarify the molecular mechanisms underlying this finding, we focused on alterations in the p53 signaling pathway in these tumors. Methods Changes in cell phenotype and func...

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Literature Corpus work
98360720-b9a1-56a0-9f83-fc9b7f1d8deb
DOI
10.21203/rs.2.22626/v2
Open publication

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Upregulation of fibronectin following loss of p53 function is a poor prognostic factor in ovarian carcinoma with a unique immunophenotypeDOI 10.21203/rs.2.22626/v2
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