Article
mRNA nuclear export and human disease.
Disease models & mechanisms - 1 Jan 2000
Hurt Jessica A, Silver Pamela A
Abstract excerpt
Export of mRNA from the nucleus is a central process in eukaryotic gene expression that has been implicated in several human diseases. Much of our understanding of how an mRNA is transported to the cytoplasm is derived from studies using yeast and fly models. We present here different mechanisms by which aberrant nuclear retention of mRNA can cause human disease. Emerging evidence that implicates the mRNA export...
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