Article

Peripheral neuropathy linked mRNA export factor GANP reshapes gene regulation in human motor neurons

2021-05-18

Abstract excerpt

<h4>SUMMARY</h4> Loss-of-function of the mRNA export protein GANP ( MCM3AP gene) cause early-onset sensorimotor neuropathy, characterised by axonal degeneration in long peripheral nerves. GANP functions as a scaffold at nuclear pore complexes, contributing to selective nuclear export of mRNAs. Here, we aimed to identify motor neuron specific transcripts that are regulated by GANP and may be limiting for local pr...

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Literature Corpus work: eb4f66c3-fb61-5cc4-bf23-86d27e9c7339
DOI: 10.1101/2021.05.18.444636

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