Article
Nuclear condensates formed by truncated mutant NEK1s impede ribosomal RNA biogenesis and drive motor dysfunction.
Nature communications - 13 Jul 2026
Wang Yixin, Hu Wen, Huang Rui, Wu Fanmin, Su Haopeng, Zang Jianye, Huang Xiaolei, Liu Yanli, Ren Haigang, Li Jian, Zhang Min, Zhang Yong, Wang Guanghui, Hao Zongbing
Abstract excerpt
NIMA-related kinase 1 (NEK1), a serine/threonine kinase, is a risk variant for amyotrophic lateral sclerosis (ALS). While the full-length NEK1 is involved in diverse cellular processes, such as DNA damage response and microtubule stability, the pathogenic mechanism of NEK1 nonsense mutations in ALS remains elusive. Here, we demonstrate that three truncated forms of NEK1 derived from ALS-related NEK1 nonsense...
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